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Fig. 5 | Genome Biology

Fig. 5

From: Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells

Fig. 5

Gene expression changes are linked to chromatin changes upon aging in B cell precursors. Log2 fold change (Aged/Young) in median read counts over peaks for H3K27me3, H3K27ac, H3K4me3, and ATAC-seq that are close to genes identified as up- or downregulated in total RNA-seq data, compared to peaks that are close only to genes whose expression is not significantly altered. Peaks were assigned to a gene if they overlapped with a window extending 1-kb up- and downstream of the gene. ANOVA was used to determine p values; these were then FDR adjusted to correct for multiple testing. Numbers above each boxplot indicate the number of peaks in each category

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Genome Biology

ISSN: 1474-760X

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