Fig. 2

Ctcf hemizygosity results in altered chromatin binding. a Differential binding analysis identified 787 CTCF binding sites differentially occupied between Ctcf hemizygous and wild-type MEFs, most of which show reduced genomic occupancy in the Ctcf ^+/− MEFs. Significant changes are shown in red (FDR < 5%). b Example genome tracks showing highly consistent loss of CTCF binding at three genomic loci overlapping the genes indicated at the top. Data are shown for the five biological replicates that passed quality control, normalized to account for sequencing depth differences. WT wild-type