Fig. 1

Loop anchor points are sites of genomic instability in cancer. a Average SNV rates per tumour within 500 kb of all LAPs. b Finer scale average SNV rates per tumour (green line) within 1 kb of LAPs, centred on the CTCF site within each LAP, with nucleosome occupancy based on MNase-seq data over the same intervals (grey line). c Average SV breakpoint rates per tumour within 500 kb of all LAPs. The 95% confidence intervals, calculated assuming a Poisson distribution of mutation rates, are shown as shaded regions in a and c. Note that the y-axis scaling has been selected to clearly depict statistically significant trends in these data