Fig. 2
From: DNA Topoisomerase I differentially modulates R-loops across the human genome
R-loop gains and losses occur on genes with distinct categories. a Breakdown of genes according to their R-loop status upon Top1 depletion; numbers indicate gene numbers in each category. b Quartile plot depicting distribution of lengths for genes undergoing R-loop gains, losses, or no/mixed change (color code is indicated below the plot). Stars (*, **, and ***) indicate p-value less than 10− 10, 10− 25,10− 40, respectively (Wilcoxon Mann-Whitney). c Gene length is plotted as a function of the fold R-loop signal change. Bins were chosen so they contain similar number of genes to avoid biased sampling. Median Pearson correlation coefficient and associated p-value are indicated. d, e Same as (b) except gene expression and gene distance are plotted. f XY plot between gene density measured on each individual chromosome (represented by a dot) and the ratio of gene numbers undergoing R-loop gains and R-loop losses upon Top1 depletion. The regression line along with 95% confidence interval and Pearson correlation coefficient are indicated. g Distribution of genes undergoing R-loop gains and losses according to the RNAP stalling and expression status of each gene. Color code is as in (b)