Fig. 4
From: DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells
DNMT3A and TET1 binding correlate with histone marks and overall gene expression. a Heatmaps showing DNMT3A1, DNMT3A2, and DNMT3B1 binding around all TSSs in mouse genome which were clustered into five groups (G1–G5) based on their different binding properties in WT ESCs. b Quantification of (a): Average occupancy of DNMT3A1, DNMT3A2, and DNMT3B1 at genes from G1–G4. c Heatmaps showing TET1 and histone marks (H3K4me3 and H3K27me3) enrichment in WT ESCs around all TSSs, listed in the same order as Fig. 4a. d Boxplots of gene expression (FPKM) from G1–G4 in WT ESCs. e Boxplot of CpG density (normalized to 100 bp) around gene promoters (− 1 kb ~ + 0.5 kb) in G1–G4