Fig. 3

DNMT3A1 binding is complementary to TET1. a Average binding occupancy of DNMT3A1 and TET1 (anti-FLAG ChIP-seq) across all canyons, normalized to same length (Start-End), and 5-kb flanking regions. b UCSC genome browser track depicts DNA methylation, TET1 (anti-FLAG and anti-TET ChIP), and DNMT3A1 binding profiles around Foxo1 gene promoter in Tet1-FLAG ESCs. c Average binding occupancy of DNMT3A1 and TET1 (anti-FLAG ChIP-seq) across all gene bodies and 3-kb flanking regions. d DNMT3A1 and TET1 binding enrichment in 1-kb genomic windows ranked by CpG density, which was displayed as a dashed line. The point where DNMT3A and TET1 lines cross on right y-axis represents roughly 1.5 CpG per 100 bp