Table 2 Characteristics of cohort of biopsy-proven NASH patients

n

40

36

/

M/F

22/18

24/12

NS ^{(Chi-Squared)}

Age (years)

58.5 ± 1.7

53.6 ± 1.9

NS (0.06)

BMI (kg/m²)

31.6 ± 0.6

32.6 ± 0.9

NS

 Glucose (mmol/L)

6.2 ± 0.3

7.0 ± 0.4

NS (0.1)

 Insulin (pmol/L)

109.6 ± 11.0

130.7 ± 12.6

NS

 HOMA2-IR

2.1 ± 0.2

2.5 ± 0.2

NS

 TAGs (mmol/L)

1.8 ± 0.2

1.9 ± 0.3

NS

 Total cholesterol (mmol/L)

4.3 ± 0.2

4.3 ± 0.1

NS

 LDL cholesterol (mmol/L)

2.6 ± 0.2

2.6 ± 0.1

NS

 HDL cholesterol (mmol/L)

1.0 ± 0.1

1.0 ± 0.03

NS

 AST (U/L)

41.5 ± 3.8

46.7 ± 3.9

NS

 ALT (U/L)

53.02 ± 3.9

72.9 ± 6.3

< 0.01*

 ALP (U/L)

118.4 ± 9.5

104.1 ± 6.7

NS

NASH activity score

2.8 ± 0.2

4.8 ± 0.2

< 0.01*

 - Steatosis

0.8 ± 0.02

2.3 ± 0.1

< 0.01*

 - Ballooning

0.7 ± 0.1

1.0 ± 0.1

0.03*

 - Inflammation

1.4 ± 0.1

1.5 ± 0.1

NS

Fibrosis

1.5 ± 0.2

1.8 ± 0.2

NS