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Table 1 Enrichment of MBNL binding site motifs in sequences upstream of alternative PAS with unknown poly(A) signal that are coupled with alternative TSS or alternative exons

From: Full-length mRNA sequencing uncovers a widespread coupling between transcription initiation and mRNA processing

Motifs Source Total Random set p value a Coupled PAS Not coupled PAS p value b
AKCCTGG DREME 1271 35 0 881 390 9.8E-44
CTSCYB Masuda, 2012 [25] 898 708 2.6E-07 442 456 9.7E-01
YGCY Purcell, 2012 [26] 2961 3139 1.0E-00 1578 1383 3.2E-02
RSCWTGSK Batra, 2014 [24] – MBNL1 145 93 4.1E-04 80 65 2.5E-01
TGCYTSYY Batra, 2014 [24] – MBNL2 95 55 6.5E-04 50 45 4.9E-01
CWGCMWKS Batra, 2014 [24] – MBNL3 1306 139 4.7E-262 870 436 1.5E-32
  Total PASs 6979 6979 3614 3338
  1. aThe enrichment of binding motifs in sequences upstream of PASs without a known poly(A) signal were calculated by Fisher’s exact test (one-sided). A randomly generated set was used as a background for enrichment analysis
  2. bPASs without significant coupling were used as the background set to identify a binding site that is enriched in the coupled PASs without a known poly(A) signal