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Fig. 8 | Genome Biology

Fig. 8

From: Dominant integration locus drives continuous diversification of plant immune receptors with exogenous domain fusions

Fig. 8

Evolutionary model of NLR-ID hotspot formation and diversification. An ancestral protein underwent duplication to form the outer clade of proteins (blue). An ancestral pair between MIC1 and C7 formed as well as the CID LRR-cap motif evolved to be MIC1-specific. Together, this enabled MIC1 to be highly amenable to new gene fusions both on genetic and protein regulatory levels. Duplications of the MIC1-C7 pair created new landing pads for IDs. Some proteins have maintained the same domain (e.g. ID1) but other proteins have undergone further diversification through the exchange of the ID domain (e.g. ID3 and ID4)

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