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Fig. 5 | Genome Biology

Fig. 5

From: Genome-wide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valleys

Fig. 5

Polycomb likely regulates hypomethylation of DMVs through TETs. a UCSC Genome Browser snapshots of DNA methylation near DMV genes Six3 and Gata6 in WT, Tet TKO, and Tet/Eed QKO mESCs. Regions with elevated DNA methylation are shaded. Tet TKO: Tet1/2/3 triple knockout, Tet/Eed QKO: Tet1/2/3/Eed quadruple knockout. b Boxplots showing the DNA methylation change (KO-WT) of Polycomb DMVs and other DMVs. P values (two-sided t test) are shown. c Boxplots showing DNA methylation level for regions within Polycomb DMVs with different CG densities in WT, Eed KO, Tet TKO, and Tet/Eed QKO mESC lines. d Boxplots showing the DNA methylation change (KO-WT) of CpG islands and non-CpG island regions within Polycomb DMVs. P values (two-sided t test) are shown

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Genome Biology

ISSN: 1474-760X

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