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Fig. 6 | Genome Biology

Fig. 6

From: Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations

Fig. 6

GalNAc-ASO-mediated Upf3b depletion in hemophilia mouse liver affects a small subset of normal transcripts. hFIX-R29X mice aged 8–14 weeks (n = 3–4) were treated every five days with six total doses of DPBS, Control-GalNAc-ASO (15 mg/kg), Upf1-GalNAc-ASO (10 mg/kg), or Upf3b-GalNAc-ASO (10 mg/kg). Animals were sacrificed 48 h after the last dose. Total RNA from livers was isolated and analyzed by transcriptome analysis. a Pie charts showing the numbers of differentially expressed genes in livers of Upf1-GalNAc-ASO treated mice compared to Control-GalNAc-ASO treated mice (left) and in livers of Upf3b-GalNAc-ASO treated mice compared to Control-GalNAc-ASO treated mice (right). b Venn diagrams comparing differentially expressed genes in livers of Upf1-GalNAc-ASO treated mice and Upf3b-GalNAc-ASO treated mice. Left: Upregulated genes. Right: Downregulated genes

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Genome Biology

ISSN: 1474-760X

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