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Fig. 2 | Genome Biology

Fig. 2

From: The multidimensional mechanisms of long noncoding RNA function

Fig. 2

Long noncoding RNAs (lncRNAs) modulate protein activities. a The lnc-DC regulates gene expression through a mechanism of action that involves its translocation to the cytoplasm, where it interacts with phosphorylated STAT3 and prevents pY705-STAT3 dephosphorylation by the tyrosine phosphatase SHP1 [49]. b The lncRNAs ncRNA-a3 and ncRNA-a7 functionally and physically associate with the Mediator complex to promote gene expression of their respective target genes. Either ncRNA-a stimulates the kinase activity of the CDK8 subunit of the complex towards the histone H3, catalysing the phosphorylation of the serine 10 (H3S10) [53]. c CONCR functions in sister-chromatid cohesion by binding and promoting the ATPase activity of DDX11 during DNA replication [54]

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