Fig. 5
Opposing responses to stress of ‘closed-loop’ Group I and IVA mRNAs. a Left: median log2 fold change for Group I–IVC mRNAs as defined by Costello et al. [13]. See Additional file 2: Figure S6A for box plot representations of this data. ∆IP change in eIF4F association (middle) and ∆TE (right) are shown for each group across each of the three stresses. Colour key in box. b, c Box plots showing the effect of change in eIF4E association with each stress (b) and ∆TE (c) on each gene cluster ∆IP denoted by a specific colour (G I red; G II blue; G IIIA and B shades of green; G IVA-C shades of purple). d Pairwise plots showing changes in IP and TE for G I and G IVA for eIF4E. Specific mRNAs are indicated with arrows. mRNA groups are denoted by a specific colour (G I red; G II blue; G IIIA and B shades of green; G IVA-C shades of purple). b–d Top ± amino acids plots, middle ± H2O2, bottom ± glucose. Equivalent plots to panels (b) and (d) for eIF4G1 and eIF4G2, respectively, are shown in Additional file 2: Figure S6B and C