Fig. 4
From: Depletion of somatic mutations in splicing-associated sequences in cancer genomes
Reduced levels of SSM at exon flanks are seen in all gene classes except in tumour suppressors. a, c SSM levels at flank and core regions of exons from oncogenes, tumour suppressors and non-cancers using TCGA exomes (a) or ICGC WGS (b) data. b, d SSM levels at flank and core regions of exons from essentials and non-essentials genes defined by CRISPR/Cas9 screen using TCGA exomes (b) or ICGC WGS (d). Statistical significance was computed using Wilcoxon signed rank test. The y-axis unit is SSM rate per bp per tumour. Error bars, 95% CI computed by bootstrapping