Fig. 5
From: Editing inducer elements increases A-to-I editing efficiency in the mammalian transcriptome
Editing at the I/V site of Kv1.1 is induced by an EIE. a Left: mfold structure prediction of the Kv1.1 transcript in the vicinity of the I/V site. The blue arrow indicates the I/V site. Right: the three Kv1.1 I/V editing reporter constructs illustrating the insertion of the EIE from GluA2 (kv1.1-Q/R EIE), the insertion of the EIE from Gabra-3 (Kv1.1-G3 EIE), and the insertion of the Gabra-3 EIE both upstream and downstream of the Kv1.1 stem loop. b Quantification of editing efficiency at the I/V site from the different Kv1.1 constructs transfected into HeLa cells, as indicated. c Quantification of editing efficiency at the I/V site from the different Kv1.1 constructs co-transfected with ADAR2 in HEK 293 cells. The mean value of the ratio between the A and G peak heights from three individual experiments was calculated as percentage of editing. Error bars are standard deviation