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Fig. 2 | Genome Biology

Fig. 2

From: Evidence of reduced recombination rate in human regulatory domains

Fig. 2

Recombination rate valleys are most prominent at functional links associated with housekeeping genes and constitutive links. a Average recombination rate in the top 10% of Hi-C pairs (observed/expected (O/E), no CTCF), associated with housekeeping genes (blue) and not associated with housekeeping genes (golden). b Average recombination rate in DNase–TSS pairs without intervening CTCF motifs, associated with housekeeping genes (purple) and not associated with housekeeping genes (golden). c Average recombination rate in enhancer–TSS pairs called by the LDA method without intervening CTCF motifs, associated with housekeeping genes (green) and not associated with housekeeping genes (golden). d Average recombination rate in ChIA-PET PolII links at early embryonic development genes and other cell type-specific genes in K562 cells. Error bars indicate the standard deviation. e The recombination rate valley is much more significant at constitutive eQTL links (orange) than that at tissue-specific eQTL links (magenta). f Recombination rate within enhancer–TSS links (10–100 kb region) called by joint LDA method in different numbers of cell types. Error bars indicate the standard deviation

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