Fig. 5
From: Sparse conserved under-methylated CpGs are associated with high-order chromatin structure
scUMC dynamics and gene expression. a Dynamic occupancy of activating histone marks in in GM12878 (coral) and H1 (green) cells at regions centered on scUMC: blood-specific, ESC-specific, or control. b Distribution of expression differences (GM12878 – H1) among target genes of blood-specific and ESC-specific scUMCs. *p value < 0.05, Wilcoxon signed-rank test, one-tail. c Representative genomic region of blood-specific scUMC target gene PDS5B. Tracks include RNA sequencing (RNA-seq) and H3K27ac, H3K4me1 ChIP-seq signal densities for GM12878 and H1 cells; chromatin interactions, Rad21 ChIA-PET for GM12878 and SMC1 for H1; CpG methylation ratios in ESCs or blood-lineage cells. The scUMC is highlighted in a greater magnification window along with Rad21, CTCF, and Znf143 ChIP-seq signal densities for GM12878 and H1 cells