Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy

Table 3 Effect of read depth, sample size, and covariate adjustment on trQTL detection

Cis radius	Reads matched^a	Samples matched^b	Adjusted for covariates	Genes tested	Genes with trQTL^c	Percentage with trQTL^c
500 kb	Yes	Yes	No	462	19	4.11%
500 kb	Yes	Yes	Yes	457	26	5.69%
500 kb	Yes	No	No	465	43	9.25%
500 kb	Yes	No	Yes	458	58	12.66%
500 kb	No	No	No	19,736	2874	14.56%
500 kb	No	No	Yes	14,586	3588	24.60%
5 kb	Yes	Yes	No	394	6	1.52%
5 kb	Yes	Yes	Yes	377	9	2.39%
5 kb	Yes	No	No	398	32	8.04%
5 kb	Yes	No	Yes	351	33	9.40%
5 kb	No	No	No	16,208	2088	12.88%
5 kb	No	No	Yes	10,304	2469	23.96%

^aAnalysis of chromsome 20 matched to 1.7 million reads corresponding to an estimated total read count of 80 million (GTEx median = 82.1 million)
^b83 non-diseased samples (GTEx left ventricle, 83)
^cFDR <0.05

ISSN: 1474-760X