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Table 3 Effect of read depth, sample size, and covariate adjustment on trQTL detection

From: Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy

Cis radius Reads matcheda Samples matchedb Adjusted for covariates Genes tested Genes with trQTLc Percentage with trQTLc
500 kb Yes Yes No 462 19 4.11%
500 kb Yes Yes Yes 457 26 5.69%
500 kb Yes No No 465 43 9.25%
500 kb Yes No Yes 458 58 12.66%
500 kb No No No 19,736 2874 14.56%
500 kb No No Yes 14,586 3588 24.60%
5 kb Yes Yes No 394 6 1.52%
5 kb Yes Yes Yes 377 9 2.39%
5 kb Yes No No 398 32 8.04%
5 kb Yes No Yes 351 33 9.40%
5 kb No No No 16,208 2088 12.88%
5 kb No No Yes 10,304 2469 23.96%
  1. aAnalysis of chromsome 20 matched to 1.7 million reads corresponding to an estimated total read count of 80 million (GTEx median = 82.1 million)
  2. b83 non-diseased samples (GTEx left ventricle, 83)
  3. cFDR <0.05