Fig. 3

Performance comparison of ReMixT with CloneHD, TITAN, Battenberg, and THetA using read re-sampling simulations. Two sets of simulations were performed, varying fraction of the descendant tumour clone (left column) and proportion of the genome with divergent copy number (right column). Boxplots show proportion of the genome for which the tool correctly called the copy number of the dominant clone (a, b), relative mean ploidy error compared to simulated (c, d), relative proportion divergent error compared to simulated (e, f), relative normal fraction estimation error compared to simulated (g, h), and relative minor clone fraction estimation error compared to simulated (i, j). Battenberg was excluded from the minor clone fraction benchmark, as it does not produce a global estimate of this parameter. Boxes show the interquartile (IQR) range with a line depicting the median. Whiskers extend 1.5×IQR above quartile 3 and below quartile 1. Diamonds show positions of outlier data points