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Fig. 1 | Genome Biology

Fig. 1

From: Identification of novel prostate cancer drivers using RegNetDriver: a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network

Fig. 1

Flow chart of the three-step computational model for identifying genetic and epigenetic alterations causing large perturbations in the tissue-specific regulatory network. Step 1 is construction of the tissue-specific regulatory network using DHS data and identification of TF hubs. Step 2 identifies significantly mutated, rearranged, and differentially methylated coding and non-coding elements and step 3 combines the output of steps 1 and 2 and outputs the effect of genetic and epigenetic alterations on TF hubs. DHS DNase I hypersensitive sites, REMC Roadmap Epigenomics Mapping Consortium, SNV single nucleotide variant, SV structural variant, TF transcription factor

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Genome Biology

ISSN: 1474-760X

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