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Table 2 Comparison of sWGS, Hi-C and deep WGS costs

From: Hi-C as a tool for precise detection and characterisation of chromosomal rearrangements and copy number variation in human tumours

 

Costs (£)a

Rearrangement detection?

Copy number detection?

Library prep

Sequencing

Total per sample

sWGS

71

30–82

101–153

N

Y

Hi-C

165

211

376

Y

Y

Deep WGS

44

1270

1314

Y

Y

  1. aBased on in-house protocols and costs using the Illumina HiSeq 4000. sWGS prepared using Illumina Nextera DNA library kit and 20–50 million 50 bp single end reads. Hi-C sequencing costs based on six samples per lane, 150 bp paired end. Deep WGS prepared using Illumina TruSeq DNA PCR-Free and one lane of 150 bp paired end sequencing (approx. 30x coverage)
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Genome Biology

ISSN: 1474-760X

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