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Table 1 Re-analysis of 17 human genes claimed as examples of horizontal gene transfer

From: Horizontal gene transfer is not a hallmark of the human genome

Gene group number Ensembl gene ID Gene name Best metazoan, non-chordate match Best non-metazoan match Explanation
Species Bit score Species Bit score Crisp et al. This study
1 ENSG00000166743, ENSG00000183747, ENSG00000005187, ENSG00000183549 Acyl-CoA synthetase medium-chain family members 1, 2A, 3, and 5 Lingula anatina or Aplysia californica 686 Desulfotomaculum thermocisternum or D. kuznetsovii 668 Bacterial HGT No HGT
2 ENSG00000047457 Ceruloplasmin (ferroxidase) Exaiptasia pallida (sea anemone) 898 Klebsormidium flaccidum (alga) 543 Plant HGT No HGT
3 ENSG00000107618, ENSG00000265203 Retinol-binding protein 3 None   Stackebrandtia nassauensis 152 Bacterial HGT Gene loss
4 ENSG00000181019, ENSG00000124588 NAD(P)H dehydrogenase, quinone 1 and 2 L. anatina or Capitella teleta 245 Sinorhizobium fredii 204 Bacterial HGT No HGT
5 ENSG00000132744 Aspartoacylase (aminocyclase) 3 Saccoglossus kowalevskii 262 Oscillatoria sp. PCC 10802 249 Bacterial HGT No HGT
6 ENSG00000170961, ENSG00000105509, ENSG00000103044 Hyaluronan synthase 1, 2, and 3 Papilio xuthus 78 Lichtheimia ramosa 333 Fungal HGT Rate variation
7 ENSG00000175806 Methionine sulfoxide reductase A Lottia gigantea 302 Pleurocapsa sp. PCC 7319 306 Bacterial HGT No HGT
8 ENSG00000095596 Cytochrome P450, family 26, subfamily A, polypeptide 1 C. teleta 396 Geitlerinema sp. PCC 7407 302 Bacterial HGT No HGT
9 ENSG00000113790 Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase L. anatina 645 Capsaspora owczarzaki 582 Protist HGT No HGT
10 ENSG00000166532 Ribosomal modification protein rimK-like family member B A. californica 143 Kitasatospora cheerisanensis 194 Archaeal HGT Rate variation
11 ENSG00000172508 Carnosine synthase 1 Crassostrea gigas 614 Perkinsus marinus 151 Protist HGT No HGT
  1. Columns 5 and 7 contain the bitscores of the best BLAST alignment to a gene from the species in columns 4 and 6. Gene group number (column 1) refers to the number used in the main text