Table 1 Re-analysis of 17 human genes claimed as examples of horizontal gene transfer
From: Horizontal gene transfer is not a hallmark of the human genome
Gene group number | Ensembl gene ID | Gene name | Best metazoan, non-chordate match | Best non-metazoan match | Explanation | |||
|---|---|---|---|---|---|---|---|---|
Species | Bit score | Species | Bit score | Crisp et al. | This study | |||
1 | ENSG00000166743, ENSG00000183747, ENSG00000005187, ENSG00000183549 | Acyl-CoA synthetase medium-chain family members 1, 2A, 3, and 5 | Lingula anatina or Aplysia californica | 686 | Desulfotomaculum thermocisternum or D. kuznetsovii | 668 | Bacterial HGT | No HGT |
2 | ENSG00000047457 | Ceruloplasmin (ferroxidase) | Exaiptasia pallida (sea anemone) | 898 | Klebsormidium flaccidum (alga) | 543 | Plant HGT | No HGT |
3 | ENSG00000107618, ENSG00000265203 | Retinol-binding protein 3 | None | Â | Stackebrandtia nassauensis | 152 | Bacterial HGT | Gene loss |
4 | ENSG00000181019, ENSG00000124588 | NAD(P)H dehydrogenase, quinone 1 and 2 | L. anatina or Capitella teleta | 245 | Sinorhizobium fredii | 204 | Bacterial HGT | No HGT |
5 | ENSG00000132744 | Aspartoacylase (aminocyclase) 3 | Saccoglossus kowalevskii | 262 | Oscillatoria sp. PCC 10802 | 249 | Bacterial HGT | No HGT |
6 | ENSG00000170961, ENSG00000105509, ENSG00000103044 | Hyaluronan synthase 1, 2, and 3 | Papilio xuthus | 78 | Lichtheimia ramosa | 333 | Fungal HGT | Rate variation |
7 | ENSG00000175806 | Methionine sulfoxide reductase A | Lottia gigantea | 302 | Pleurocapsa sp. PCC 7319 | 306 | Bacterial HGT | No HGT |
8 | ENSG00000095596 | Cytochrome P450, family 26, subfamily A, polypeptide 1 | C. teleta | 396 | Geitlerinema sp. PCC 7407 | 302 | Bacterial HGT | No HGT |
9 | ENSG00000113790 | Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | L. anatina | 645 | Capsaspora owczarzaki | 582 | Protist HGT | No HGT |
10 | ENSG00000166532 | Ribosomal modification protein rimK-like family member B | A. californica | 143 | Kitasatospora cheerisanensis | 194 | Archaeal HGT | Rate variation |
11 | ENSG00000172508 | Carnosine synthase 1 | Crassostrea gigas | 614 | Perkinsus marinus | 151 | Protist HGT | No HGT |