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Table 1 Selected non-synonymous mutations identified by the C580Y-like and C580-vector-like temporal analyses and GWAS
| Gene annotation | Gene ID | Chromosome | Amino acid change | Method |
|---|---|---|---|---|
| Phosphatidylinositol 4-kinase, putative | PF3D7_0419900 | 4 | S915G | C580Y-like |
| Sec14 domain-containing protein | PF3D7_0626400 | 6 |
L498F N615D | C580Y-like |
| Ubiquitin-protein ligase, putative (Hrd3) | PF3D7_1448400 | 14 | S57T | C580Y-like |
| Ubiquitin carboxyl-terminal hydrolase, putative | PF3D7_0104300 | 1 | R3138H | C580Y-like |
| HSP40, subfamily A, putative | PF3D7_1437900 | 14 | P383H | C580Y-vector-like |
| Sentrin-specific protease 2, putative (SENP2) | PF3D7_0801700 | 8 | H423Y | C580Y-like |
| kelch protein, putative | PF3D7_1022600 | 10 | P623T | GWAS (mutant kelch13) |
| kelch protein, putative | PF3D7_1343700 | 13 | C580Y | GWAS (all samples) |
