Fig. 6

a Proportion of sites showing differential allelic methylation, histone occupancy, and gene expression. All four combinations of high and low methylation rate, histone occupancy rate, and gene expression are compared, described from the perspective of the high methylation allele, and whether this allele is the one with high or low histone occupancy, and high or low gene expression (note that high methylation allele with low histone occupancy also refers to the low methylation allele with high histone occupancy). For the histone marks b H3K27ac, c H3K4me1, d H3K36me3, and e H3K27me3, we show the proportions of all the differential allelic methylation, histone occupancy, and gene expression tested (blue), and proportions of the tested sites that passed significance p < 0.05 (red). f The percentage of allelic differentially modified histone sites as identified by GSCI that have an ASM ratio at the SNP-associated CpG in the top 1% versus the percentage of histone sites not having an allelic effect detected by GSCI but having an ASM ratio at the SNP-associated CpG in the top 1%