Fig. 5

Performance analysis in presence of doublets. Effect of presence of doublets on V-measure index (panel a) and mean absolute error of cellular prevalences (panel b) across multiple values for the total number of single cells (specified as m on top of each panel). Each box plot represents 10 simulated datasets each with 10 genotypes and 48 genomic loci. The cells are sampled from a multinomial distribution with a sample size of m and parameters equal to the true prevalence of each genotype. Progressively increasing the percentage of doublet cells results in minor degrading performance in cellular prevalence estimate. Overall, this result suggests that ddClone’s cellular prevalence estimates are robust to the presence of uncorrected doublet noise