Fig. 5
From: Identifying aggressive prostate cancer foci using a DNA methylation classifier
Validation of the PC aggressiveness classifier. a Manhattan plot of the probabilities calculated for 100 randomly selected samples from TCGA PC cohort. The color bar at the bottom of the plot designates the sample types determined by TCGA. Black = adjacent normal prostate, yellow = primary PC. The black dotted line marks the probability threshold used. b Distribution of the prediction of TCGA tumor and AN samples. c Evaluation of correctly predicted samples based on the histological microscopic examinations performed by TCGA. NPV negative predictive value, PPV positive predictive value