Fig. 2
From: DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases
a Manhattan plot depicting the –log10(P values) of the associations between all CpG sites and CRP, adjusted for age, sex, BMI, cell distributions, technical covariates, and smoking. The dotted lines indicate the Bonferroni threshold of 1.15 × 10−7 for significance. The red dots indicate positive significant associations between methylation and CRP, the blue dots indicate negative significant associations. b QQ plot showing observed vs. expected − log10(P values) for association at all CpG sites