Fig. 4

Transcriptome regulation mirrors changes in energy metabolism. Differentially expressed genes (Additional file 1: Table S2) mapped onto main energy metabolism pathways using the KEGG mapper tool. Growth on glycerol led to expression changes of carbon metabolism genes. Genes induced or repressed on glycerol relative to glucose are coloured in red and blue, respectively, with fold changes indicated in parentheses. Metabolites and pathways that may be up- or down-regulated, judged by gene expression changes, are highlighted in red and blue, respectively. Hexose transporters and other sugar metabolism genes are indicated on yellow background (top left). The pyruvate transporters Mcp1 and Mcp2 and the citrate importer SPAC17H9.08 (green) are mentioned in the text, but their expression levels were not significantly altered. Coloured squares indicate selected genes whose expression profiles after a shift to glycerol are shown in Additional file 2: Figure S13