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Fig. 4 | Genome Biology

Fig. 4

From: Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures

Fig. 4

Pan-cancer analysis of TIS association with antigen presenting machinery (APM) gene expression. a The association between the median APM score and the median T cell infiltration score across 19 tumor types. The sizes of the circles are proportional to the within-cohort Spearman correlation between TIS score and APM score. KIRC and LUAD are among the highest not only for APM score but also for the APM–TIS correlation. b The APM score differences between tumors and adjacent normal tissue in kidney and lung neoplasms. Each circle is the APM score of a tumor (red) or an adjacent normal (blue) sample. No significant tumor-normal differences are observed in lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), or kidney chromophobe (KICH) at α = 0.05. However, clear cell and papillary renal cell carcinoma (KIRC and KIRP) tumors significantly overexpress APM genes. The Benjamini–Hochberg adjusted p values are reported in the figure (Mann–Whitney test)

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Genome Biology

ISSN: 1474-760X

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