Skip to main content

Table 4 Differentially expressed genes in ASD and co-morbidities that overlap with innate immunity pathways

From: Integrative analysis of genetic data sets reveals a shared innate immune component in autism spectrum disorder and its co-morbidities

  Toll-like receptor signaling pathway Chemokine signaling pathway NOD-like receptor signaling pathway Leukocyte transendothelial migration pathway
Autism spectrum disorder TLR9, MAP2K4, CCL4, LY96, CCL4, JAK2, GRK7, CCL17, BIRC3, MAPK13, SUGT1, PSTPIP1, TXK, NCF2, JAM2, GNAI2, GNAI3,
  CD14, TAB2, MAP2K2, MAPK13, CCL21, CCL22, GNB3, GNAI2, PYCARD, TAB2, BIRC2 CLDN23, ACTN3, ICAM1, ACTN1, MAPK13,
  MAP2K1, TBK1, TLR1, TLR2 CCR2, CXCR3, GNAI3, CCR10,   CD99, RAP1B, CLDN14, MSN
   ADCY6, PREX1, HCK, MAP2K1,   
   RAP1B   
Asthma STAT1, IKBKE, NFKB1, RELA, STAT1, CCL2, GNB4, JAK2, CXCL1, RIPK2, BIRC3, CCL2, TXK, ACTN2, ICAM1
  TLR7, TICAM1, IL8, IFNAR1, CCL20, NFKB1, RELA, CXCL5, IL8, CASP5, NFKB1, RELA,  
  IFNAR2, TICAM2, CD40, CXCL9, XCR1, PLCB1, CXCL1, PRKCD, CXCL2, IL6  
  TLR3, IL6, IRF7 HCK, IL8, CCL1, CXCL2,   
   CXCL9, LYN   
Chronic kidney disease JUN, CTSK, NFKBIA, FOS CCL17, NFKBIA, CXCR6 NFKBIA, HSP90AA1, NLRC4, CLDN16, ACTN4, CLDN9
    HSP90AB1  
Cerebral palsy CD14 CCL2 CCL2 JAM3, MMP2, VCAM1, ACTN4, ACTG1,
     MSN, CTNNA3
Dilated cardiomyopathy MYD88, LY96, CD14, NFKBIA, CCL2, CCL11, CCL8, NFKBIA, RIPK2, CCL2, CCL11, CCL8, PIK3R1
  MAP2K1, PIK3R1 MAP2K1, CCR1, PIK3R1 NFKBIA  
Ear infection JUN, CD86, STAT1, CCL3, STAT3, STAT1, STAT2, CCL2, CASP8, CXCL1, RIPK2, TNF, TXK, NCF4, VCAM1, PIK3R5, CLDN23,
  MYD88, CCL5, CCL4, LBP, CCL3, CCL5, CCL4, CX3CR1, BIRC3, CCL2, CCL5, CCL11, CLDN10, CLDN8, MYL9, CLDN5, ICAM1,
  TLR6, MAP3K8, CD14, IKBKE, CCL11, CCL7, CXCL14, JAK3, CCL7, MEFV, CASP1, TNFAIP3, ACTN4, CLDN19, CLDN22, RASSF5,
  NFKB1, NFKBIA, PIK3R5, TLR5, JAK2, CCL17, CCL20, CCL19, MAPK3, NFKB1, NFKBIB, NFKBIA, CLDN7, CLDN4, PIK3R2
  ITIRAP, RELA, TOLLIP, CXCL11, CCL22, NFKB1, NFKBIB, NFKBIA, IL18, RELA, IL1B, NLRP3,  
  TLR7, TLR8, CXCL10, CASP8, PIK3R5, RELA, GNG7, FGR, GNG11, BIRC2, CXCL2, IL6  
  TNF, IL12B, MAP2K3, MAP2K1, GNGT2, XCL1, CXCL5, ADCY3, CXCL11,   
  MAP2K6, MAPK3, IL1B, CD40, ADCY2, CXCL10, CXCL1, PLCB3,   
  TBK1, CXCL9, TLR3, TLR4, CXCR5, CXCR2, GNG8, HCK,   
  TLR1, FOS, TLR2, IL6, MAP2K1, CCR5, CCR7, MAPK3,   
  IRF7, PIK3R2 CXCL16, CCR1, CXCL13, CXCL2,   
   CXCL3, CXCL9, LYN, PIK3R2   
Epilepsy
  Toll-like receptor signaling pathway Chemokine signaling pathway NOD-like receptor signaling pathway Leukocyte transendothelial migration pathway
Inflammatory bowel disease CD86, MYD88, CCL4, LY96, CCL2, CCL4, CCL11, CCL7, CHUK, CXCL1, BIRC3, CCL2, TXK, ITGA4, NCF4, MMP9, NCF2,
  MAP3K8, AKT1, CD14, CTSK, AKT1, CCL18, ARRB2, CCL20, CARD6, CCL11, CCL7, IL8, MYL12A, THY1, GNAI2, MYL5, RHOH,
  SPP1, TOLLIP, CXCL11, TLR8, GNG5, GNB3, GNB2, CCL24, CASP5, CASP1, MAPK3, IL1B, CLDN8, MYL9, CLDN15, MYL12B, RAP1A,
  CXCL10, TICAM1, CHUK, IL8, PRKX, GNG10, GNAI2, GNG11, NLRP1, CXCL2, HSP90AB1 PIK3CA, MSN, VAV3
  MAP2K3, IL12A, MAPK3, IRF3, XCL1, CXCL11, CXCL6, CCR10,   
  IL1B, PIK3CA, CXCL9, TLR4, CXCL10, ADCY6, CHUK, CXCL1,   
  TLR1, TLR2 PLCB3, CXCR2, CXCR1, HCK,   
   IL8, ADCY4, PRKCZ, MAPK3,   
   CCR1, XCL2, CXCL13, RAP1A,   
   PF4, CXCL2, CXCL3, PF4V1,   
   PIK3CA, CXCL9, PPBP, VAV3,   
   LYN   
Bacterial and viral infection TLR9, MYD88, CCL5, LY96, STAT3, STAT2, CCL5, DOCK2, CHUK, RIPK2, CCL5, NOD1, TXK, ITGAM, NCF4, MMP9, NCF2, VAV1,
  CD14, NFKBIA, TLR5, TLR8, JAK2, VAV2, NRAS, NFKBIA, CARD6, CCL8, CARD8, CASP5, VASP, MYL12A, VAV2, ITGB2, CTNNA1,
  CHUK, IRAK4, MAP2K7, IRF3, GNG7, GNG5, GNB2, GNG10, NOD2, NFKBIA, IKBKG, PYCARD, GNAI3, EZR, PLCG1, RHOH, PRKCA,
  IKBKG, TICAM2, IL1B, TBK1, GNG11, ADCY3, CXCR3, CCL4L1, NLRC4, IL1B, BIRC2 ESAM, RAC2, CD99, ITK, NCF1, CYBA,
  TLR4, TLR1, FOS, TLR2, GNAI3, GNB1, SOS2, CHUK,   CYBB, MYL5, RHOA
  IRF7 RAF1, RHOA, CXCR2, CXCR1,   
   PRKCD, HCK, RAC2, RASGRP2,   
   ADCY4, CCR3, CCR4, CXCR6,   
   CCR7, GRB2, IKBKG, HRAS,   
   GSK3B, CCR1, ITK, NCF1,   
   PPBP, LYN   
Muscular dystrophy LY96, CD14, CTSK, SPP1, GNG10, HCK, MAP2K1, GNG12 PYCARD JAM3, MMP2, NCF2, VCAM1, ITGB2,
  MAP2K1, FOS    JAM2, MYL5, CD99, ACTG1, MYL12B,
     MSN, CYBA
Schizophrenia CD99
Upper respiratory infection CCL4, CXCL11, CXCL10, IFNB1, STAT2, CCL2, CCL4, CCL7, CCL2, CCL7, IL6
  CXCL9, IL6, IRF7 CXCL11, CXCL10, CXCL9   
  1. ASD autism spectrum disorder