Fig. 2

Distribution of probes on the HM450 and EPIC platforms. a, b Venn diagrams indicating overlap of (a) Type I and (b) Type II CpG probes on the HM450 and EPIC platforms. c Distribution of probes across different genome annotation categories: (1) GENCODE19 genes; (2) CpG islands; and (3) regulatory regions defined using ENCODE DNAse hypersensitivity sites and FANTOM5 enhancers. Probes are separated according to whether they are new to EPIC (‘EPIC new’, blue, n = 413,743) or common to HM450 and EPIC (‘EPIC/HM450’, purple, n = 450,161). d–f Fraction of (d) DNase proximal peaks, (e) DNase distal peaks and (f) FANTOM 5 enhancers which overlap more than one, two or three HM450 probes (red), EPIC probes (blue) or genomic CpG sites (grey)