Fig. 2

General levels of drug sensitivity in a panel of cancer cell lines. a The proportion of variability in the data explained by each of the PCs of the fully imputed drug sensitivity (IC₅₀) data matrix in CGP. PCs are arranged by associated eigenvalue. b Histogram of Spearman correlations of the IC₅₀ values of all 138 drugs in CGP with PC1 of the fully imputed IC₅₀ matrix. c Boxplot of PC1 (estimated in all 714 cell lines) against tissue-of-origin in CGP. Boxes are colored by cancer type