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Fig. 7 | Genome Biology

Fig. 7

From: An alternative novel tool for DNA editing without target sequence limitation: the structure-guided nuclease

Fig. 7

SGN can edit endogenous genes in the zebrafish genome. a Schematic (top) shows the positions of gDNAs on the target GFP gene. Sequencing result (bottom) shows a mutated molecular of #5-15 (Table 1) with a large deletion. b Schematic (top) shows the positions of gDNAs on the target znf703 gene. Sequencing result (bottom) from the genome edited products shows that 754 bp were removed with another 11 bp deleted downstream. c Schematic (top) shows the positions of gDNAs on the target cyp26b1 gene. Sequencing result (bottom) from the genome edited products shows that 2610 bp were removed. The red arrows indicate the positions where large fragment deletion occurs

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