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Table 5 Multivariate model that regresses epigenetic age acceleration on participant characteristics in the Bogalusa study. Coefficients and p values from regressing measures of intrinsic and extrinsic epigenetic age acceleration on participant characteristics from dataset 2

From: An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease

Multivariate linear regression Intrinsic EAA Extrinsic EAA
   Estimate (SE) Z p Estimate (SE) Z p
Race Caucasian vs. African American –0.013 (0.316) –0.04 0.97 0.843 (0.316) 2.67 0.0076
Gender Female vs. Male –0.622 (0.278) –2.24 0.025 –0.718 (0.277) –2.60 0.0093
Education Grade 8–9 vs. < Grade 8 1.583 (1.468) 1.08 0.28 2.177 (1.465) 1.49 0.14
  Grade 10–12 vs. < Grade 8 1.285 (1.27) 1.01 0.31 2.267 (1.267) 1.79 0.074
  Vocat/Tech vs. < Grade 8 0.307 (1.299) 0.24 0.81 1.921 (1.295) 1.48 0.14
  College vs. < Grade 8 0.85 (1.281) 0.66 0.51 2.375 (1.277) 1.86 0.062
  Graduate vs. < Grade 8 0.147 (1.336) 0.11 0.91 1.53 (1.332) 1.15 0.25
Diabetes (II)   0.173 (0.485) 0.36 0.72 0.012 (0.483) 0.03 0.98
Hypertension   0.539 (0.291) 1.86 0.064 1.247 (0.29) 4.30 1.7 × 10-5
R-squared   0.025    0.043