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Table 4 Logistic model that regresses CHD status on epigenetic age acceleration and participant characteristics in the WHI. Coefficients, Wald Z statistics, and corresponding p values resulting from regressing CHD status on measures of epigenetic age acceleration and various participant characteristics. The results for the measure of IEAA and EEAA can be found in columns 2 and 3, respectively

From: An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease

Logistic model. Outcome CHD case status Intrinsic EAA Extrinsic EAA
Covariates   Estimate (SE) Z p Estimate (SE) Z p
Epig. Age Accel   –0.017 (0.01) –1.72 0.085 –0.006 (0.008) –0.74 0.458
Age   0.027 (0.008) 3.44 0.001 0.028 (0.008) 3.52 4.3 × 10-4
Race/ethnicity Hispanic vs. African American 0.083 (0.152) 0.55 0.584 0.118 (0.153) 0.77 0.443
  White vs. African American 0.141 (0.135) 1.04 0.298 0.135 (0.135) 1.00 0.319
HDL-cholesterol   –0.02 (0.005) –4.29 1.8 × 10–5 –0.02 (0.005) –4.33 1.5 × 10-5
Triglyceride   0.001 (0.001) 1.43 0.153 0.001 (0.001) 1.38 0.169
Insulin   0.002 (0.001) 2.26 0.024 0.002 (0.001) 2.25 0.024
Glucose   0.005 (0.002) 2.64 0.008 0.005 (0.002) 2.64 0.008
CRP   0.013 (0.008) 1.61 0.107 0.013 (0.008) 1.61 0.108
Creatinine   0.518 (0.281) 1.84 0.065 0.515 (0.281) 1.84 0.067
BMI   –0.011 (0.01) –1.19 0.235 –0.012 (0.01) –1.22 0.223
Education High school (HS) vs. no HS –0.058 (0.183) -0.32 0.753 –0.067 (0.183) –0.37 0.715
  Some College vs. no HS 0.008 (0.164) 0.05 0.96 –0.004 (0.165) –0.03 0.979
  College vs. no HS –0.198 (0.223) –0.89 0.373 –0.219 (0.223) –0.98 0.327
  Grad school vs. no HS –0.237 (0.183) –1.29 0.196 –0.251 (0.183) –1.37 0.171
Alcohol Past drinker vs. Never –0.6 (0.514) –1.17 0.243 –0.641 (0.513) –1.25 0.212
  Light drinker vs. Never –0.34 (0.233) –1.46 0.145 –0.343 (0.233) –1.47 0.141
  Moderate vs. Never –0.1 (0.32) –0.31 0.754 –0.096 (0.32) –0.30 0.764
  Heavy vs. Never –0.34 (0.381) –0.89 0.373 –0.337 (0.381) –0.88 0.377
Smoking Former vs. Current –0.997 (0.467) –2.13 0.033 –0.989 (0.467) –2.12 0.034
  Never vs. Current –1.321 (0.468) –2.82 0.005 –1.317 (0.468) –2.81 0.005
Diabetes   0.706 (0.196) 3.61 3.0 × 10-4 0.699 (0.196) 3.58 3.4 × 10-4
Hypertension   0.565 (0.103) 5.46 4.8 × 10-8 0.559 (0.103) 5.41 6.3 × 10-8