Table 4 Logistic model that regresses CHD status on epigenetic age acceleration and participant characteristics in the WHI. Coefficients, Wald Z statistics, and corresponding p values resulting from regressing CHD status on measures of epigenetic age acceleration and various participant characteristics. The results for the measure of IEAA and EEAA can be found in columns 2 and 3, respectively
From: An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease
Logistic model. Outcome CHD case status | Intrinsic EAA | Extrinsic EAA | |||||
|---|---|---|---|---|---|---|---|
Covariates | Estimate (SE) | Z | p | Estimate (SE) | Z | p | |
Epig. Age Accel | –0.017 (0.01) | –1.72 | 0.085 | –0.006 (0.008) | –0.74 | 0.458 | |
Age | 0.027 (0.008) | 3.44 | 0.001 | 0.028 (0.008) | 3.52 | 4.3 × 10-4 | |
Race/ethnicity | Hispanic vs. African American | 0.083 (0.152) | 0.55 | 0.584 | 0.118 (0.153) | 0.77 | 0.443 |
White vs. African American | 0.141 (0.135) | 1.04 | 0.298 | 0.135 (0.135) | 1.00 | 0.319 | |
HDL-cholesterol | –0.02 (0.005) | –4.29 | 1.8 × 10–5 | –0.02 (0.005) | –4.33 | 1.5 × 10-5 | |
Triglyceride | 0.001 (0.001) | 1.43 | 0.153 | 0.001 (0.001) | 1.38 | 0.169 | |
Insulin | 0.002 (0.001) | 2.26 | 0.024 | 0.002 (0.001) | 2.25 | 0.024 | |
Glucose | 0.005 (0.002) | 2.64 | 0.008 | 0.005 (0.002) | 2.64 | 0.008 | |
CRP | 0.013 (0.008) | 1.61 | 0.107 | 0.013 (0.008) | 1.61 | 0.108 | |
Creatinine | 0.518 (0.281) | 1.84 | 0.065 | 0.515 (0.281) | 1.84 | 0.067 | |
BMI | –0.011 (0.01) | –1.19 | 0.235 | –0.012 (0.01) | –1.22 | 0.223 | |
Education | High school (HS) vs. no HS | –0.058 (0.183) | -0.32 | 0.753 | –0.067 (0.183) | –0.37 | 0.715 |
Some College vs. no HS | 0.008 (0.164) | 0.05 | 0.96 | –0.004 (0.165) | –0.03 | 0.979 | |
College vs. no HS | –0.198 (0.223) | –0.89 | 0.373 | –0.219 (0.223) | –0.98 | 0.327 | |
Grad school vs. no HS | –0.237 (0.183) | –1.29 | 0.196 | –0.251 (0.183) | –1.37 | 0.171 | |
Alcohol | Past drinker vs. Never | –0.6 (0.514) | –1.17 | 0.243 | –0.641 (0.513) | –1.25 | 0.212 |
Light drinker vs. Never | –0.34 (0.233) | –1.46 | 0.145 | –0.343 (0.233) | –1.47 | 0.141 | |
Moderate vs. Never | –0.1 (0.32) | –0.31 | 0.754 | –0.096 (0.32) | –0.30 | 0.764 | |
Heavy vs. Never | –0.34 (0.381) | –0.89 | 0.373 | –0.337 (0.381) | –0.88 | 0.377 | |
Smoking | Former vs. Current | –0.997 (0.467) | –2.13 | 0.033 | –0.989 (0.467) | –2.12 | 0.034 |
Never vs. Current | –1.321 (0.468) | –2.82 | 0.005 | –1.317 (0.468) | –2.81 | 0.005 | |
Diabetes | 0.706 (0.196) | 3.61 | 3.0 × 10-4 | 0.699 (0.196) | 3.58 | 3.4 × 10-4 | |
Hypertension | 0.565 (0.103) | 5.46 | 4.8 × 10-8 | 0.559 (0.103) | 5.41 | 6.3 × 10-8 | |