Fig. 3

Intrinsic epigenetic age acceleration versus African or European Ancestry. a-c DNA methylation age (y-axis) versus chronological age (x-axis) in (a) Women’s Health Initiative, (b) Bogalusa study. Dots corresponds to participants and are colored by race/ethnicity (green = African Ancestry, gray = Caucasian). The gray line depicts a spline regression line through Caucasians. We define two measures of age acceleration based on DNAm age. c, d The bar plots relate the universal measure of epigenetic age acceleration to race/ethnicity, which is defined as residual to the spline regression line through Caucasians. e, h Results after combining the two blood datasets using Stouffer’s meta-analysis method. f, g The y-axis reports the mean value of IEAA, which is defined as residual from a multivariate regression model that regresses DNAm age on age and several measures of blood cell counts. Each bar plot reports 1 standard error and the p value from a group comparison test (ANOVA)