Fig. 2

Intrinsic epigenetic age acceleration in Tsimane, Hispanics, East Asians, and Caucasians. a-c DNA methylation age (y-axis) versus chronological age (x-axis) in (a) dataset 5, (b) dataset 6, (c) dataset 7. Dots corresponds to participants and are colored by race/ethnicity (green = African American, gray = Caucasian, blue = Hispanic, red = Tsimane, orange = East Asians). The gray line depicts a spline regression line through Caucasians. We define two measures of age acceleration based on DNAm age. d-f The bar plots relate the universal measure of epigenetic age acceleration to race/ethnicity, which is defined as residual to the spline regression line through Caucasians, i.e. the vertical distance of a point from the line. g-i The y-axis reports the mean value of IEAA, which is defined as residual from a multivariate regression model that regresses DNAm age on age and several measures of blood cell counts. Each bar plot reports 1 standard error and the p value from a group comparison test (ANOVA)