Fig. 2
![Fig. 2](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13059-016-1011-3/MediaObjects/13059_2016_1011_Fig2_HTML.gif)
Single-cell WGBS is an accurate and reproducible method for genome-wide 5mC analysis. a 5mC promoter methylation status of 58 liver-specific genes. b Merged single cells have the same methylation pattern as their corresponding bulk. Each comparison is based on 10,000 randomly chosen 3-kb windows indicates the number of single cells sequenced. c Principal component analysis of single cells and bulk shows separate clustering of fibroblasts and hepatocytes (both panels) and hepatocytes from old and hepatocytes from young mice