Table 6 Performance metrics under simulation scenario 4 (high precision)
From: An evaluation of methods correcting for cell-type heterogeneity in DNA methylation studies
Method | Number of false positives | Power | KS | GIF | \(\hat {K}\) |
|---|---|---|---|---|---|
Unadjusted | 368 | 0.600 | 0.142 | 1.32 | – |
Ref-based | 64 | 0.460 | 0.043 | 1.04 | – |
Ref-free | 437 | 0.694 | 0.101 | 1.36 | 13 |
SVA | 79 | 0.534 | 0.032 | 1.09 | 11 |
ISVA | 198 | 0.522 | 0.062 | 1.20 | 14 |
EWASher | 16 | 0.072 | 0.038 | 0.94 | – |
CellCDec | 54 | 0.546 | 0.031 | 1.05 | – |
Deconf | 58 | 0.520 | 0.014 | 1.02 | – |
RUV | 155 | 0.568 | 0.051 | 1.15 | 32 |