Table 4 Performance metrics under simulation scenario 2 (no confounding)
From: An evaluation of methods correcting for cell-type heterogeneity in DNA methylation studies
Method | Number of false positives | Power | KS | GIF | \(\hat {K}\) |
|---|---|---|---|---|---|
Unadjusted | 38 | 0.642 | 0.059 | 1.09 | – |
Ref-based | 13 | 0.594 | 0.030 | 0.90 | – |
Ref-free | 366 | 0.704 | 0.058 | 1.25 | 14 |
SVA | 79 | 0.646 | 0.015 | 1.06 | 10 |
ISVA | 408 | 0.654 | 0.061 | 1.27 | 15 |
EWASher | 0 | 0.126 | 0.066 | 0.83 | – |
CellCDec | 14 | 0.650 | 0.021 | 0.93 | – |
Deconf | 50 | 0.652 | 0.031 | 0.92 | – |
RUV | 134 | 0.640 | 0.007 | 1.00 | 38 |