Fig. 7
From: Beyond comparisons of means: understanding changes in gene expression at the single-cell level
Post hoc offset correction for cell-cycle data set. Upper panels display posterior medians for LFC in overall expression against the weighted average between estimates of overall expression rates for G1, S and G2M cells (weights defined by the number of cells in each group). Lower panels illustrate the effect of the offset correction upon the empirical distribution of posterior estimates for mRNA content normalizing constants \(\phi ^{(p)}_{j}\). These figures illustrate a shift in mRNA content throughout cell-cycle phases. In particular, our model infers that cellular mRNA is roughly duplicated when comparing G1 to G2M cells. LFC log-fold change