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Fig. 5 | Genome Biology

Fig. 5

From: Widespread RNA binding by chromatin-associated proteins

Fig. 5

Chromatin-associated proteins prefer specific sequence motifs. We searched for motifs that have high mutual information with the fRIP/input differential expression statistic using FIRE (“Materials and methods”). Motifs discovered for HUR (a), HNRNPH1 (b), and HNRNPU (c) matched well to known motifs in the RBPmap database [64]. For each motif, we plotted the empirical cumulative density function of the fRIP/input statistic for genes with and without the motif. Below that, we plotted the 25th, 50th, and 75th percentiles of the fRIP/input statistic for genes containing the specified number of motif occurrences. We discovered novel motifs at similar levels of significance for CAPs SUZ12 (d), CBP (e), and HDAC1 (f)

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