Fig. 5

ADARB1 Alu exon inclusion isoform encodes an active RNA editing enzyme with altered editing activity. a The schematic diagram of the protein domain structure of ADARB1 isoforms and supporting peptide sequences from the PRIDE database. b The change in overall RNA editing levels of 7,618 RNA editing sites in HEK293 cells upon ectopic expression of the exon skipping (Short) or the exon inclusion (Long) ADARB1 isoform as compared to the empty vector (EV) control. Error bars show standard errors calculated based on the 7,618 known RNA editing sites used in this analysis. c Common and isoform-specific differentially edited sites upon ectopic expression of the Alu exon inclusion (Long) or skipping (Short) ADARB1 isoform. Isoform-specific differentially edited sites are further classified (low-confidence, high-confidence) based on the strength of the RNA-seq evidence