Fig. 4
From: Meta-analysis of RNA-seq expression data across species, tissues and studies
Clustering by species or tissue is predictably dependent on the subset of tissues selected and the divergence times of the species analyzed. a Inter-tissue distance (JSD½) between Lin2 and GTEx human samples overlaid with line y = x. b The distance (JSD½) between matched tissues among species plotted as a function of evolutionary time for all tissues and species assessed in the Brawand and Merkin studies (n = 43). c Clustering heat map of 51 human tissues sequenced by GTEx. Distances represent the mean inter-tissue distance calculated among three individuals. Colored boxes indicate the flat clusters (groupings) formed for distance cutoffs corresponding to the mean interspecies tissue distance at specific divergence times. Tissues within a cluster have an inter-tissue distance lower than the mean interspecies distance between matched tissues. MYA million years ago