Fig. 4

Co-localization of SHP and SREBP-2 binding sites in hepatic genomes. a A Venn diagram showing the overlap between the binding peaks of SHP and SREBP-2 [20] in hepatic chromatin. Peaks with at least 1 bp overlap were designated as overlapping. b Heat map analysis showing overlapping binding peaks of SHP and SREBP-2 in vehicle- or FGF19-treated group (SHP SREBP2 overlapping); SHP peaks present in both groups (SHP conserved); and peaks present in only one group as indicated (predominant). c Normalized ChIP-seq peaks for SHP and SREBP-2 at selected sterol biosynthetic networks are displayed (UCSC genome browser)