Fig. 1

Genomic distribution of hepatic SHP binding and motif analysis of SHP binding regions. a Venn diagrams showing the numbers of SHP binding peaks in hepatic chromatin and nearby genes (parentheses) in mice treated with vehicle or FGF19 for 2 h. b Distances from the center of SHP binding peaks to the TSS. c Genomic distribution of SHP binding peaks in the vehicle- or FGF19-treated group. d Logos showing the common sequences detected with highest confidence (E-value) at the SHP binding peak regions. For each common sequence motif, up to the top three transcription factors that potentially bind to the motif are shown