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Fig. 2 | Genome Biology

Fig. 2

From: The estrous cycle surpasses sex differences in regulating the transcriptome in the rat medial prefrontal cortex and reveals an underlying role of early growth response 1

Fig. 2

Sexually biased genes in the rat medial prefrontal cortex (mPFC) are associated with cellular communication and translation. a Enrichment map depicting the clusters of differentially modulated pathways between females and males identified by the gene-set enrichment analysis. The area of each node, representing a gene set (functional pathway), corresponds to the number of genes of the gene set it contains, and the edge thickness is proportional to the number of genes overlapping between the two connected nodes. Pathways related to the interaction with the extracellular matrix and its downstream signaling were widely associated with males, while only pathways related to translation and oxidative phosphorylation were associated with the female phenotype. b Illustration of the averaged read coverage for the male (blue), proestrus (pink), and diestrus (green) groups for two genes up-regulated (left) or down-regulated (right) in females when compared to males. c A substantial proportion of the genes differentially expressed in proestrus or diestrus when compared to males are specific to each cycle stage. d Enrichment map depicting the cluster of pathways identified by gene-set enrichment analysis as differentially regulated in the proestrus versus males (inner circle of each node), and diestrus versus males comparisons (outer ring of each node). Green and blue edges correspond to the proestrus versus males, and diestrus versus males datasets, respectively

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