Fig. 1
From: ZIFA: Dimensionality reduction for zero-inflated single-cell gene expression analysis
Zero-inflation in single-cell expression data. a Illustrative distribution of expression levels for three randomly chosen genes showing an abundance of single cells exhibiting null expression [15]. b Heat maps showing the relationship between dropout rate and mean non-zero expression level for three published single-cell data sets [3, 5, 14] including an approximate double exponential model fit. c Flow diagram illustrating the data generative process used by ZIFA. d Illustrative plot showing how different values of λ in the dropout-mean expression relationship (blue lines) can modulate the latent gene expression distribution to give a range of observed zero-inflated data