Fig. 8

Models linking promoter activity with inclusion of ‘promoter-like’ exons. Looping model (a): physical interactions between TSS and the genomic region corresponding to the alternative exon facilitates exon inclusion (left), while absence of such interactions leads to more skipping of ‘promoter-like’ exons (pink). Alternative TSS model (b): the activation of an alternative TSS in the proximity of the genomic region corresponding to the alternative exon facilitates exon inclusion (left), while the inactivation of the TSS closer to the ‘promoter-like’ exon promotes its skipping