Fig. 4

Telomeric and sub-telomeric regions in the MCF-10A genome display increased interaction frequencies. a Scaling plot of interaction frequencies against genomic distance for the MCF7 and MCF10A genomes. The MCF10A genome showed increased interaction frequency at genomic distances >200 Mb, suggesting telomere/sub-telomere associations. b Quantification of the interaction frequency between the telomeric regions (5 % of the ends by length) of each chromosome in MCF7 and MCF10A. The p value was determined by Wilcoxon rank-sum test. Scaling plots of MCF-10A and MCF-7 for chr1 (c), chr2 (d), chr7 (e), and chr3 (f). Chromosomes 1, 2 and 7 displayed an increased interaction frequency at large distances in MCF-10A but chromosome 3 did not. Scaling plots of individual chromosome arms for chr1 (g), chr2 (h), and chr7 (i)